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Carvedilol part 1


محاضرة 4

Carvedilol



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هنبدأ كلاس تانية انهاردة

Class:
Blocks alpha-1 receptors and nonselective beta-receptors to decrease BP.

This drug works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This effect lowers heart rate, blood pressure, and strain on the heart.


Carvedilol

هو الوحيد اللى فى الكلاس دى فى مصر


بيشتغل على مستقبلات الفا 1 والبيتا بانواعها

هناخد حتة  فارما صغيرة كده

Alpha-Blockers


cause vasodilation






types


nonselective beta-receptors






three types of beta receptor,
β1, β2 and β3 receptors
β1-adrenergic receptors are located mainly in
the heart and in the kidneys

β2-adrenergic receptors are located mainly in
the lungs, gastrointestinal tract, liver, uterus, vascular smooth muscle, and skeletal muscle


β3-adrenergic receptors are located in
fat cells




الادوية بتاعة المحاضرات اللى فاتت كانت بتشتغل على بيتا 1 بس
Atenolol
Metoprolol
Bisoprolol


الادوية فى السوق المصرى






















Indication and dosage


. Hypertension
initially12.5mg once daily increased
after 2 days to usual dose of 25mg once daily;if
necessary may be further increased at intervals of a
least 2 weeks to max. 50mg daily in single or divided
doses; ELDERLY initial dose of 12.5mg daily may
provide satisfactory control



.


Angina



initially12.5 mg twice daily,increased after 2
days to 25 mg twice daily














. Adjunct in heart failure
Initially 3.125mg twice daily (withfood) dose increased at
Intervals of atleast 2weeks to 6.25mg twice daily,
Then to12.5mg twice daily, then to 25 mg twice daily
Increase to highest dose tolerated, max .25mg twice
Daily in patients with severe heart failure or body-
Weight less than 85 kg and 50mg twice daily in
Patients over 85kg













It is also used after a heart attack to improve the chance of survival
. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.





What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

 


 

 

 

What happens if I overdose?




Seek emergency medical attention




Overdose symptoms may include

uneven heartbeats,


shortness of breath



, bluish-colored fingernails


, dizziness
دوخة



, weakness
ضعف


, fainting
اغماء


Seizure (convulsions).



Pregnancy Category C

تحت ارشاد الطبيب





Nursing Mothers

There are no data on the excretion of carvedilol into human milk
تحت ارشاد الطبيب







How should I take carvedilol?

Do not take in larger or smaller amounts or for longer than recommended



Carvedilol works best if you take it with food.




Take carvedilol at the same time every day.





Do not skip doses or stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.



You may open the carvedilol capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Discard the empty capsule.




If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.






Your blood pressure will need to be checked often. Visit your doctor regularly.







If you need surgery, tell the surgeon ahead of time that you are using carvedilol. You may need to stop using the medicine for a short time.





Carvedilol can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using carvedilol before surgery unless your surgeon tells you to.



Carvedilol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.





Store at room temperature away from moisture and heat.









What should I avoid while taking carvedilol?






Carvedilol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.







Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol Also avoid taking medicines or other products that might contain alcohol.
Alcohol may cause the carvedilol in to be released too quickly into the body. Check the labels of any prescription or over-the-counter medicines you take to see if they contain alcohol (also called ethanol).
وخصوصا ادوية الكحة



Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
تجنب الوقوف السريع


نتابع المحاضرة القادمة

Side effect
Contraindication
Drug interreaction 




لينك المحاضرات السابقة









Reference
   Drugs.com
    Bnf 61
    Medicinenet.com

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