Carvedilol part 1

محاضرة 4

Carvedilol

اضغط على اى صورة للتكبير

هنبدأ كلاس تانية انهاردة

Class:

Blocks alpha-1 receptors and nonselective beta-receptors to decrease BP.

This drug works by blocking the action of certain natural chemicals in your body (such as epinephrine) that affect the heart and blood vessels. This effect lowers heart rate, blood pressure, and strain on the heart.

Carvedilol

هو الوحيد اللى فى الكلاس دى فى مصر

بيشتغل على مستقبلات الفا 1 والبيتا بانواعها

هناخد حتة  فارما صغيرة كده

Alpha-Blockers

cause vasodilation

types

α₁-blockers

α₂-blockers

nonselective beta-receptors

three types of beta receptor,

β₁, β₂ and β₃ receptors

β₁-adrenergic receptors are located mainly in

the heart and in the kidneys

β₂-adrenergic receptors are located mainly in

the lungs, gastrointestinal tract, liver, uterus, vascular smooth muscle, and skeletal muscle

β₃-adrenergic receptors are located in

fat cells

الادوية بتاعة المحاضرات اللى فاتت كانت بتشتغل على بيتا 1 بس

Atenolol

Metoprolol

Bisoprolol

الادوية فى السوق المصرى

Indication and dosage

. Hypertension

initially12.5mg once daily increased

after 2 days to usual dose of 25mg once daily;if

necessary may be further increased at intervals of a

least 2 weeks to max. 50mg daily in single or divided

doses; ELDERLY initial dose of 12.5mg daily may

provide satisfactory control

.

Angina

initially12.5 mg twice daily,increased after 2

days to 25 mg twice daily

. Adjunct in heart failure

Initially 3.125mg twice daily (withfood) dose increased at

Intervals of atleast 2weeks to 6.25mg twice daily,

Then to12.5mg twice daily, then to 25 mg twice daily

Increase to highest dose tolerated, max .25mg twice

Daily in patients with severe heart failure or body-

Weight less than 85 kg and 50mg twice daily in

Patients over 85kg

It is also used after a heart attack to improve the chance of survival

. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

 

 

 

 

What happens if I overdose?

Seek emergency medical attention

Overdose symptoms may include

uneven heartbeats,

shortness of breath

, bluish-colored fingernails

, dizziness

دوخة

, weakness

ضعف

, fainting

اغماء

Seizure (convulsions).

Pregnancy Category C

تحت ارشاد الطبيب

Nursing Mothers

There are no data on the excretion of carvedilol into human milk

تحت ارشاد الطبيب

How should I take carvedilol?

Do not take in larger or smaller amounts or for longer than recommended

Carvedilol works best if you take it with food.

Take carvedilol at the same time every day.

Do not skip doses or stop taking carvedilol without first talking to your doctor. Stopping suddenly may make your condition worse.

You may open the carvedilol capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Discard the empty capsule.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Your blood pressure will need to be checked often. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using carvedilol. You may need to stop using the medicine for a short time.

Carvedilol can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using carvedilol before surgery unless your surgeon tells you to.

Carvedilol is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Store at room temperature away from moisture and heat.

What should I avoid while taking carvedilol?

Carvedilol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid drinking alcohol within 2 hours before or after taking extended-release carvedilol Also avoid taking medicines or other products that might contain alcohol.

Alcohol may cause the carvedilol in to be released too quickly into the body. Check the labels of any prescription or over-the-counter medicines you take to see if they contain alcohol (also called ethanol).

وخصوصا ادوية الكحة

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

تجنب الوقوف السريع

نتابع المحاضرة القادمة

Side effect

Contraindication

Drug interreaction 

لينك المحاضرات السابقة

http://www.facebook.com/groups/169085283118724/doc/276659129028005/

Reference

   Drugs.com

    Bnf 61

    Medicinenet.com